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Mindful is a phase II test that examines mild cognitive loss with brain inflammation or XPRO in patients with Alzheimer’s disease. In this study, XPRO is compared to a placebo compared to determine the effects of female, daily functioning and its effects on behavior. In addition, the test assesses the safety and tolerance of XPRO.
XPRO, given as a subcutaneous injection once-a week, is the inhibitor of the next generation of the tumor necrosis factor (TNF).
A total of 208 participants are nominated in the study, including 92 individuals with mild cognitive loss (MCI) and 116 with mild Alzheimer’s disease. The primary closing point in Mindful trials changes from baseline in cognitive scores measured with cognitive overall (EMACC) of the initial and mild Alzheimer’s.
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