A saturated fats centered in pamitic acid, meat and dairy can promote the metastatic capacity of cancer cells through the fat receptor CD36.
Metastasis formation is the main cause of death in cancer patients. In this way most people die of cancer – not with primary tumor, but cancer is spreading from the body. “it is estimated It is responsible for ~ 90% of metastasis cancer deaths, ”and despite our modern medical armament, there has been little progress in preventing proliferation. In fact, we can sometimes do sometime Make matters worse. In an editorial of “therapy-inspired metastasis”, its authors “provide evidence that all general remedies including radiotherapy, chemotherapy, fine needle biopsy, surgical processes and anesthesia have the ability to contribute to tumor progression.” You can imagine cutting around a tumor and separating blood vessels can lead to “migration of residual tumor cells”, but why chemotherapy? How can chemo can be to ruin Metastasis? “Despite reducing the size of the primary tumor, the chemotherapy tumor changes microelement” – around the surrounding tissues – “resulting in an increased migration of cancer cells in the bloodstream.” Sometimes, chemo, surgery and radiation are completely appropriate, but, again, other times, these treatment can make cases worse. If only we had a way to treat the cause of the spread of cancer.
Antimatastatic remedies have been developed Obstructed From the fact that cells starting metastasis are unknown. Then, a landmark study was published: “Targeting metastasis-intact cells through fatty acid receptor CD36.” Researchers found a sub -grouper of human cancer cells found “unique in their ability to start metastasis”; They all express high levels of a fat receptor known as CD36, relaxed me “Fat controller.” It is discovered that especially pamitic acid or high -fat diet Increases Metastatic capacity of these cancer cells. Where is pomitic acid found? Although it was originally Discovered In palm oil, pomitic acid is the most concentrated in meat and dairy. “Emerging evidence Show He serves as a signaling molecule that regulates pamitic acid (PA), a common fatty acid in human diet, progression and growth of many diseases at molecular levels. “This is a saturated fat that is Recognized By CD36 receptors on cancer cells, and we know it has to be blamed, because if the CD36 receptor is blocked, there are metastasis.
The study was of a human cancer, but it was a human cancer that was transplanted into mice. However, the presence of clinically (meaning in cancer patients itself), these CD36-steded metastasis-inchieving cells is actually correlated with the diagnosis of a poor disease. CD36 appears To drive For example, progress of brain tumor. As seen down in my video down and in the survival decreasing at 3:21 What is the cause of cancer to metastasize?Low CD36 people with tumors manifested Use to live Importantly for a long time. it Is Also with the mortality rate of breast cancer: “In this study, we have corrected the death rate of breast cancer patients for tumor CD36 expression levels.” This is not surprising, because “CD36 plays an important role in proliferation, migration and growth of breast cancer cells.” If we stop CD36, we can prevent “Migration and invasion of breast cancer cells.”
Bottom and 3:46 in me Videoyou can Look CD36 Before and after prohibition, breast cancer cell migration and invasion. (Top lines with circles are before the CD36 prohibition, and the lines below with the squares are later.)
it Not there. Only “human melanoma- and breast cancer-rich tumors” either. Now we suspect that “CD36 expression Drive The progression of ovarian cancer and metastasis, “also, because we can prevent ovarian cancer cell invasion and migration, as well as block CD36 and block both lymph node and blood-generated metastasis. Look The same effect with prostate cancer; Press the fats of fat by prostate cancer cells and press the tumor. All this was studied with receptor-fierce drugs and antibodies in a laboratory setting. If these ”metastasis-initating cancer cells especially rely On diet lipid [fat] To promote metastasis, “The spread of cancer, why does the diet not block fat in the first place only?
“Lipid metabolism fuel Dissemination of cancer. Cancer cells like fat and cholesterol. Stored in fat. “Therefore, CD36+ metastatic cells can avail this feature to get high amounts of energy, which is likely to be necessary for them to survive on sites away from the anchor and primary tumor” – install a shop throughout the body.
“Time when glucose [sugar] Was Agreed As a major, if not only, fuel is over to support cancer cell proliferation. “Appears there Happen “A thick way to metastasize.” No wonder high -fat diet (HFD) “can play an important role in increasing the risk of different cancer types, and many clinical studies have combined HFD with many advanced cancer.”
If the diet can “be” fat “Smoothness The wheels of the cancer machine, “maybe” Spacei ‘C Dietary Regiment “, we can use dietary fat to starve cancer? You don’t know until you put it in the test, which we will look forward.
