In the 41st annual meeting of the European Society of Human Reproduction and Embryology (Eshre) today a new study suggests that women with polycystic ovary syndrome (PCOS) have separate intestinal microbyota and metabolic signatures which are related to preform and metabolic signature and have a high risk of adequate pregnancy.

Research highlights rapid decrease in beneficial intestine bacteria Abstraction ,P. Merde,, Brankade-chain with high levels of amino acids (BCAAS), especially an essential amino acid involved in isolaucene-protein production and energy metabolism. Together, these changes can act as potential drivers of poor endometrial functions and reproductive complications in women with PCOS.

PCOS is a major cause of infertility, affecting one of the five women of reproductive age globally. Although reproductive remedies are often successful in helping PCOS conceive women, they remain at high risk of complications such as abortion, preterm births and pregnancy diabetes. So far, the mechanisms behind this high risk remain unclear.

The lead author of the study, Dr. Ixia Liu said, “In clinical practice, we noticed that even younger women with PCOS achieved pregnancy, who are still facing unexpectedly high rates of abortion and other complications”. “Many of these women also had metabolic imbalances and digestive issues, inspiring us to detect potential interplays Intestine microbiotaMetabolites, and transmit the uterus. ,

Possible studies followed 220 women under the age of 35 in 44 cities in China, including 110 PCOS patients and 110 matching controls. Researchers used a combination of intestine Microbiom To profile the gap between groups and conducted laboratory studies on endometrial stromal cells (ESCs) to assess metabolomics and aging and disruptions, important procedure for embryo implantation.

The results showed a significant decrease in microbial diversity among PCOS patients, especially in decrease P. MerdeA species associated with metabolic health. Serum Metabolomics reduced the level of fatty acids in the BCAAS, especially the high levels of the isolucine and the PCOS group.

Despite a similar pregnancy rate, women with PCOS were almost double (1.95 times) to experience at least one adverse pregnancy results, including abortion, preterm birth, macrosomia, low birth weight, gestational diabetes, hypertension disorders, and childbirth.

Further investigation revealed that the level of the isoleuusin was also elevated in the endometrial tissue. When researchers highlighted the ESC for the isolucine in the laboratory, they saw the increased markers of cellular sexense and reduced the lower capacity for discdulation. Dr. “These conclusions indicate changes in the uterus, which were long before the expectation,” Liu said. “Our data suggests high isolyusin levels and disadvantages P. Merde Endometrial health can also affect health in women under 35. ,

Researchers proposed P. Merde And BCAAS can serve as a biomarker to identify high -risk PCOS patients and guide individual treatment approaches in the future. “The next step is to find out if dietary intervention, probiotics, or BCAA-stake diets can reverse these effects and improve pregnancy results”, Dr. Liu concluded.

The study provides compelling evidence that metabolism and microbial imbalance in PCOS are not only systemic, but can reduce direct endometrial receptivity, even in young women. These findings are an important step towards personal reproductive care in PCOS. ,

Prof. Dr. Anees Faki, Chairman of Ashre

Study essence will be published in today Human reproductionOne of the world’s major reproductive medicine magazines.