The study focused on adults with inactive, locally recurrent, or metastatic squamous cell carcinoma of the anal canal (SCAC), which had not received systemic chemotherapy earlier.

According to the company, the Pod1um-303/Interaact2 test results have shown that the study performed a statistically significant improvement in the progress-free survival (PFS), which did not already treated with systemic chemotherapy or death at risk of paclitaxel, which had already been treated with systemic chemotherapy, paclitaxela, which was already treated with ineffective local recurrent or metastatic SCACs, which is already treated with ineffective local recurrent or metastatic SCAC. Clinically decreased by 37% meaningful. Patients from the retiftenalimabs and chemotherapy combination groups achieved an average PFS of 9.3 months compared to 7.4 months for patients in the Placebo combination group.

In May 2025, the FDA approved the first-line treatment of adult patients in combination with carbopltin and paclitaxel (Platinum-based chemotherapy) to the first-line treatment of adult patients in combination with carbopltin and paclitaxel (Platinum-based chemotherapy). In addition, the FDA provided approval for Zynyz as a single agent for the treatment of adult patients with local recurrents or with metastatic SCAC with the progression of the disease for platinum-based chemotherapy.

Incyte has also presented a type of II Variation Marketing Authority App to European Medicine Agency (EMA) for Retifanlimab at Advanced SCAC and a Japanese new drug application by Pharmaceuticals and Medical Devices Agency (PMDA) in March 2025 (J-NDA) by Pharmaceuticals and Medical Devices Agency (PMDA) in March 2025 (J-NDA) A Japanese New Drug Application (J-NDA) is approved for Retifanline.

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