Tuesday, May 20, 2025
Poly-Metabolite score may reduce dependence on self-reported diet data in large population studies.
For the first time, researchers at the National Institute of Health (NIH) identified the patterns of metabolites in blood and urine, which can be used as a purpose measurement of a person’s energy consumption from ultra-managed foods. After converting the body into energy, metabolites are left, a process known as metabolism. Scientists used these figures to develop a score based on several metabolites, known as a poly-matabolite score, which has the ability to reduce dependence, or complement the use of self-reported diet data in large population studies. Conclusions appeared on May 20, 2025 PLOS Medicine,
“The limitations of self-reported diet are well known. Metabolomics provides an exciting opportunity to improve our ways to measure complex exposure not only as diet and ultra-sensitive foods, but also to understand the mechanisms that can affect the dietary health of the national cancer,” NIH’s major investigators of NIH, “NIH’s leading investigators Arikka Lafefield, MPH Said.
High diets in ultra-developed foods, which are defined as ready-to-Eat or Ready-to-Heat, are associated with industrially manufactured products, usually lower in high and essential nutrients in calories, with some types of cancer, including obesity and increased risk of chronic diseases. Large population studies determine the health effects of ultraprosed foods that usually depend on the data made from the dietary questionnaire. Such measures may be subject to differences in reporting and may not be responsible for changes in food supply over time. As a result of this study, researchers now have an objective measurement of the intake of ultra-like food to help pursue the study of associations between ultra-based foods and health results.
In new studies, researchers used data from several existing studies to identify the patterns of metals and metabolites in the blood and urine which were related to ultra-produced food intake. Overview data came from 718 old adults, who provided biospasimes and dietary information during the 12 -month study period. Experimental data came from a small clinical trial of 20 adults at the NIH Clinical Center, who consumed a high diet in ultraProcered foods (80% energy) and a diet that included any ultravocated food (0% of energy), which is in random order for two weeks.
Researchers found hundreds of metabolites that were correlated with the percentage of energy from ultra-related foods in the diet. Using machine learning, researchers identified metabolic patterns associated with high intake of ultra-transmitted foods and calculated a separate poly-metabolite score for blood and urine. Additional trials found that these scores may accurately differentiate within the testing subjects between highly processed dietary phase and disappointed dietary phase.
Study participants were large American adults whose diets may vary from other population, as a result, conclusions would have to be repeated in other age groups. Researchers recommended that these poly-metabolite scores are evaluated and the population is improved with various diets and is a wide range of ultra-like food intake. Additionally, future research should check the risk of these poly-matabolite scores and the risk of diseases such as cancer and type 2 diabetes.
About National Cancer Institute (NCI): NCI leads the National Cancer Program and efforts to reduce the spread of NIH cancer and improve the lives of people suffering from cancer. The NCI supports a wide range of cancer research and training through grants and contracts. NCI’s intramaral research program conducts innovative, transdiciplinary basic, translation, clinical and epidemicical research on the causes of cancer, the world’s largest research hospital, including research at NIH Clinical Center, the world’s largest research hospital. Learn more about intramural research conducted in NCI Cancerous epidemiology departmentFor more information about cancer, please visit NCI website Cancer.gov Or call NCI’s Cancer Information Service 1-800-4-Cancer (1-800-422-6237).
About National Institute of Health (NIH): NIH, the country’s medical research agency, includes 27 institutions and centers and is a component of the US Health and Human Services Department. NIH is the primary federal agency that is conducting and supporting basic, clinical and translational medical research, and is investigating the causes, treatments and treatment for both common and rare diseases. For more information about Nih and its programs, travel www.nih.gov,
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Reference
Abar L, Steel EM, Lee SK, Kahle L, Moore SC, Vats E, et al. , Plos med 22 (5): https://doi.org/10.1371/journal.pmed.1004560
