Breast cancer is one of the most common cancer in women in the United States. Thanks to the fundamental research of decades, it is also one of the most curables. Exception is a particularly aggressive version known as triple-negative breast cancer (TNBC). This is 10 to 15 percent of all breast cancer cases. This inconsistently affects young and African American women. No effective treatment exists. Cold Spring Harbor Laboratory Professor David Spector and Graduate Student Venbo in a new discovery Molecular cancer researchA magazine of the American Association for Cancer Research can help first.

The group’s group researches the role of RNA called Long Non-Coding RNAS in the formation of cancer. They now come to know that rarely studied LNCRNA, which is first implicated in gastric cancer, also plays a role in TNBC. It is called Linc01235Spctor lab found Linc01235 Human breast tumor orgenoids-when sequencing RNA on three-dimensional cancer models. A link was suspected between Xu, who led the project Linc01235 And TNBC when reviewing data from cancer genome atlas, a database of over 11,000 cancer patients. Suggested the expression of data Linc01235 Breast cancer NFIBAlready connected to TNBC.

Nevertheless, it was known about “very little” NFIB Nothing else next to Linc01235Says the speaker. Therefore, the team decided to “engrossing deep into it”. He had important questions: “How does it work in the cell? Which procedures can it join? We came to the interesting story that it sits in the genome and the gene that it controls.”

To test the concept of Xu, the team knocked out Linc01235 In cancer cells using crispr. Separately, they knocked it into cancer cells and organoids using antisancy molecules. In both experiments, he found that reducing the production of RNA also decreased. NFIB Expression When this happened, the TNBC organoid formation was suppressed.

Our findings show that Linc01235 Controls positively NFIB Transcription. This controls the notch route, affecting cell proliferation in TNBC progression. ,

Venbo Zoo, Graduate Students

Scientists require more research to find potential treatment for TNBC. However, the speaker says, these conclusions highlight the importance of non-coding RNA in the discovery: “The goal here is to understand the mechanisms by which the cell function and disease state takes the tasks, perhaps to regulate an RNA molecule or reduce the RNA molecule.

Each series has another link. so, Linc01235 Provides an important step in the right direction.