ADA2 regulates inflammation through lysosomal and extracellular mechanisms
Adenosine Deminus 2 (ADA2) plays an important role in immune regulation, especially in monocyte discrimination and activation. Unlike Ada1, which mainly serve intracellularly, the ADA2 can be secreted or smuggled to lysosomes. Decreased ADA2 (DADA2) due to impaired discrimination in TNF-α levels, highly supporters inflammatory cytokine production, and monocytes, impaired discrimination in anti-inflammatory M2 macrophages. […]
